Science & Research

Science & Research

I'm-Yunity® is Based on Sound Research

I’m-Yunity® is a well-researched mushroom health supplement made from the mycelium extract of Yunzhi mushroom (Coriolus Versicolor). Over the last 20 years, our company group has supported studies including clinical trials to identify the active ingredient groups of polysaccharopeptide (PSP) and demonstrate its immune health benefits in the body. Following are a few key findings. (To receive more information about PSP research, please email us at ( This email address is being protected from spambots. You need JavaScript enabled to view it. )

Strong Immunity as Strong Protection

Phase I (21 cases, 1 hospital), Phase II (485 cases, 8 hospitals) and Phase III (650 cases, 14 hospitals) randomized controlled clinical trials showed that our Yunzhi polysaccharopeptide (PSP) supports normal immune function and benefits general well being. These results were reflected in the increase in the activity of natural killer cells, increase in the production of interleukin-2 and increase in the ratio of helper T cells (CD4+) to cytotoxic T cells (CD8+) in comparison with the control group.

The above are all immune cells and proteins responsible for guarding against and killing any foreign bodies and abnormal cells in the body. Their increase suggests our Yunzhi polysaccharopeptide (PSP) possess immune supporting benefits and potentially can enhance our immune surveillance.

Maintaining White Blood Cell Levels

Another clinical study carried out by clinical oncologists successfully showed Yunzhi polysaccharopeptide (PSP) was able to maintain white blood cell counts in comparison with a control group. Additionally recently published phase II (34 cases) double-blind, placebo-controlled and randomized clinical trial reported that study subjects taking polysaccharopeptide for four weeks (PSP) had significant improvement in their white blood cell and neutrophil counts, serum Immunoglobin G and Immunoglobin M (two types of antibodies in the serum of blood) (p<0.05) compared with their pretreatment values.

Increased Immune Proteins

Other experimental studies suggest our Yunzhi polysaccharopeptide (PSP) can induce the increase of cytokines (immune proteins) such as an increase in α and γ-interferon production and an increase of helper T cells (CD4+) under certain experimental conditions. Moreover, Yunzhi polysaccharopeptide (PSP) was shown to activate macrophages, which secrete tumour necrosis factors and other reactive intermediates to mediate immunomodulatory effects. An animal study also suggested Yunzhi polysaccharopeptide (PSP) may counteract the depressive effect of certain drugs on white blood cell counts and interleukin-2 production.

Looking at Drug-Herb Interactions

The most recent clinical study conducted in the US investigated the ability of I’m-Yunity® to inhibit or induce the drug metabolism of CYP3A4 in healthy adult human subjects by using an erythromycin breath test (EBT). A 14-day course of I’m-Yunity® was not associated with any clinically significant CYP3A4 inhibition or induction. This suggests that the administration of I’m-Yunity® with other medications and dietary supplements which are primarily metabolized by CYP3A4, a subtype of the P450 enzyme pathway, is not expected to be associated with significant herb-drug interactions.



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